Local Business Buzz: New Openings in the Lowcountry (May 2026)
What’s new, what’s next and what’s shaping the Lowcountry
Story by Bailey Gilliam
May brings steady momentum across the Lowcountry. Spring has settled in, and early promise is turning into real progress. “Coming soon” is becoming open doors, while new plans continue to take shape. This month’s Business Buzz tracks the openings, expansions and ideas driving the local economy into one of its busiest seasons.
Now Open in the Lowcountry
Bark & Bubbles
Lady’s Island
Now open at 12 Fairfield Road, Suite 3A, Bark & Bubbles offers grooming, daycare and overnight boarding in a calm, thoughtfully designed space. With a gentle approach and 24/7 online booking, it is a strong addition for local pet owners north of the Broad.
Sea Pines Pottery
Hilton Head Island
At The Shops at Sea Pines Center, Sea Pines Pottery invites guests to slow down and create. Choose a piece, make it your own, and return for a glazed, food-safe keepsake. Ideal for a quiet afternoon, a celebration or a paint-and-sip night.
Terrace + Tide
Hilton Head Island
A new outdoor living destination is now open at 13 New Orleans Road, offering a curated mix of high-quality patio furniture, from lounge collections and dining sets to umbrellas, fire tables and finishing accents designed to handle the Lowcountry climate. Whether outfitting a full backyard or refreshing a porch for the season ahead, Terrace + Tide offers both inspiration and expertise for living well outside.
Fleet Feet Bluffton
Bluffton
Fleet Feet has opened in Okatie Village with a focus on fit and function. Using 3D foot scanning and gait analysis, the store matches customers with the right shoes and gear, then builds community through training programs and group runs.
Hilton Head Pharmacy
Hilton Head Island
Hilton Head Pharmacy is now open at 5 Park Lane, expanding a trusted Bluffton-based pharmacy to the island. The full-service location offers prescription care, immunizations, health screenings and free delivery, along with specialized compounding for hormone therapy, dermatology, pain management and veterinary needs. Led by pharmacists Rob Vaughn and Cole Holloway, the team combines modern convenience with personalized, community-focused care.
Coming Soon
Cosmetic Skin & Laser Center & RegenCen
Bluffton
Opening soon on Persimmon Street, CSLC & RegenCen will offer personalized aesthetic care focused on natural, long-term results. Each visit begins with a complimentary consultation tailored to individual goals.
MUSC Health Bluffton Medical Pavilion
Bluffton
Set to open this spring at 700 Buckwalter Towne Blvd., this 54,000-square-foot facility will bring primary care, specialty services and a Hollings Cancer Center clinic together for more convenient, coordinated care.
May River Crossing developments
Bluffton
Growth continues with a new CVS under construction, a proposed Chipotle and plans for a Beaufort Memorial medical office and Fifth Third Bank branch. The expansion adds convenience to one of Bluffton’s busiest corridors.
Business News
A fresh look for a local staple
The Farmers Market of Bluffton has unveiled a new logo and poster by artist Amiri Farris, inspired by local farmers, coastal landscapes and Gullah-Geechee traditions. Limited signed prints give residents a chance to take home a piece of Bluffton’s story.
Be The Buzz
Discover a new business gem in the Lowcountry? Share your find. Email details to info@wearelocallife.com to help us spotlight the newest local treasures.
